Mass spectrometry reveals potential of b-lactams as SARS-CoV-2 Mpro inhibitors

Please use this identifier to cite or link to this item: http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/11209

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DC Field	Value	Language
dc.contributor.author	Malla, T.R.	-
dc.contributor.author	Tumber, A.	-
dc.contributor.author	John, T.	-
dc.contributor.author	Brewitz, L.	-
dc.contributor.author	Strain-Damerell, C.	-
dc.contributor.author	Owen, C.D.	-
dc.contributor.author	Lukacik, P.	-
dc.contributor.author	Henry Chan, H.T.	-
dc.contributor.author	Pratheesh, M.	-
dc.contributor.author	Salah, E.	-
dc.contributor.author	Duarte, F.	-
dc.contributor.author	Yang, H.	-
dc.contributor.author	Rao, Z.	-
dc.contributor.author	Walsh, M.A.	-
dc.contributor.author	Schofield, C.J.	-
dc.date.accessioned	2025-04-21T03:27:58Z	-
dc.date.available	2025-04-21T03:27:58Z	-
dc.date.issued	2021	-
dc.identifier.uri	http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/11209	-
dc.description.abstract	The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro assay. The results reveal some b-lactams, including penicillin esters, are active site reacting Mpro inhibitors, thus highlighting the potential of acylating agents for Mpro inhibition.	en_US
dc.language.iso	en	en_US
dc.publisher	Royal society of Chemistry	en_US
dc.title	Mass spectrometry reveals potential of b-lactams as SARS-CoV-2 Mpro inhibitors	en_US
dc.type	Article	en_US
Appears in Collections:	Pharmacy

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