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http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/534| Title: | A Medicinal Chemistry Perspective on 4-Aminoquinoline Antimalarial Drugs |
| Authors: | Neill, O. Paul, M. Ward Stephen, A. Berry Neil, G. Jeyadevan, J.P Biagini Giancarlo, A. Asadollaly Egbaleh Park, B.K. Bray Patrick, G. |
| Keywords: | Plasmodium falciparum chloroquine resistance transporter (PfCRT);antimalarial;chloroquine (CQ) resistance;combinatorial chemistry;drug-design;drug-metabolism;plasmodium falciparum |
| Issue Date: | 5-Mar-2006 |
| Publisher: | Bentham Science Publishers |
| Abstract: | A broad overview is presented describing the current knowledge and the ongoing research concerning the 4- aminoquinolines (4AQ) as chemotherapeutic antimalarial agents. Included are discussions of mechanism of action, structure activity relationships (SAR), chemistry, metabolism and toxicity and parasite resistance mechanisms. In discussions of SAR, particular emphasis has been given to activity versus chloroquine resistant strains of Plasmodium falciparum. Promising new lead compounds undergoing development are described and an overview of physicochemical properties of chloroquine and amodiaquine analogues is also included. |
| URI: | http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/534 |
| Appears in Collections: | Chemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Jeyadevan,A Medicinal Chemistry Perspective on 4.pdf | 172.81 kB | Adobe PDF |  View/Open |
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