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Please use this identifier to cite or link to this item: http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/534
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dc.contributor.authorNeill, O.
dc.contributor.authorPaul, M.
dc.contributor.authorWard
dc.contributor.authorStephen, A.
dc.contributor.authorBerry
dc.contributor.authorNeil, G.
dc.contributor.authorJeyadevan, J.P
dc.contributor.authorBiagini
dc.contributor.authorGiancarlo, A.
dc.contributor.authorAsadollaly
dc.contributor.authorEgbaleh
dc.contributor.authorPark, B.K.
dc.contributor.authorBray
dc.contributor.authorPatrick, G.
dc.date.accessioned2014-07-16T06:00:51Z
dc.date.accessioned2022-07-11T08:25:14Z-
dc.date.available2014-07-16T06:00:51Z
dc.date.available2022-07-11T08:25:14Z-
dc.date.issued2006-03-05
dc.identifier.urihttp://repo.lib.jfn.ac.lk/ujrr/handle/123456789/534-
dc.description.abstractA broad overview is presented describing the current knowledge and the ongoing research concerning the 4- aminoquinolines (4AQ) as chemotherapeutic antimalarial agents. Included are discussions of mechanism of action, structure activity relationships (SAR), chemistry, metabolism and toxicity and parasite resistance mechanisms. In discussions of SAR, particular emphasis has been given to activity versus chloroquine resistant strains of Plasmodium falciparum. Promising new lead compounds undergoing development are described and an overview of physicochemical properties of chloroquine and amodiaquine analogues is also included.en_US
dc.language.isoenen_US
dc.publisherBentham Science Publishersen_US
dc.subjectPlasmodium falciparum chloroquine resistance transporter (PfCRT)en_US
dc.subjectantimalarialen_US
dc.subjectchloroquine (CQ) resistanceen_US
dc.subjectcombinatorial chemistryen_US
dc.subjectdrug-designen_US
dc.subjectdrug-metabolismen_US
dc.subjectplasmodium falciparumen_US
dc.titleA Medicinal Chemistry Perspective on 4-Aminoquinoline Antimalarial Drugsen_US
dc.typeArticleen_US
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